Minzu Road, Wuhan, 430074, R.P. China
their action mechanism study ;
Apr. 2015~Mach. 2017
School of Medicine, Yale University
From Sep. 2001 to Jun. 2011
College of Pharmacy, Chengdu University of Traditional Chinese Medicine
●Chemical constituent separation and
●Biosassay combination chemical method for quality control and evaluation for TCM;
●Comparative Medicine of International Traditional Medicine.A.
Governmental
2017
Principle Investigator(PI),Key methods for quality control and new drug development of Ethnic medicine, National Major Scientific and Technological Special Project for “Significant New Drugs Development” (No. 2017ZX09301060-001), 2017-2020, amount ￥1,223,000
2017
Principle Investigator(PI), “Investigation on the effectiveness substance identification and quality control of Chinese Herbal Medicine based on efficacy tropism and spectrum-effect relationship grey correlation analysis ”, National Natural Science Foundation of China (N0. 81773893) , 2018-2021, amount ￥550,000
2015
Principle Investigator(PI),Herbal drugimprovement by active ingredients knock in and knock out, take Sodium aescinate as an example,Hubei Nature Science Foundation (N0. 2015CFB302) , 2015-2016, amount ￥30,000
2015
Principle Investigator(PI),“Investigation on the molecular mechanism”, Young Talents of Science and Technology in Wuhan Morning Program, 2015-2016, ￥100,000
2012
Principle Investigator(PI), ”Investigation of the processing effecting on Chinese herbal medicine ascending and descending tropism by multi-modality biological imaging”, National Natural Science Foundation of China (N0. 81202935) , 2012-2015, amount ￥230,000
[1] Liang Shuai(1), Deng Xin (1), Lei Lei, Zheng Yao, Ai Jiao, Linlin Chen, Zhinan Mei, Yung-Chi Cheng(*) and Yongshen Ren(*). The comparative study of the therapeutic Effects and mechanisms of Baicalin, fBaicalein and their Combinations on ulcerative colitis rat Fronters in Pharmacology Ethnopharmacology. 2019, https://doi.org/10.3389/fphar.2019.01466 【SCI二区，IF=3.831】
[2] Ren Yongshen(*,1), Lei Lei(1), Deng Xin, Zheng Yao, Li Yan, Li Jun, Mei Zhinan (*). Novel application of neural network modelling for multicomponent herbal medicine optimization. Sci Rep.https://doi.org/10.1038/s41598-019-51956-6【SCI三区，IF=4.011】
[3] Feifei Zhang(1), Jie Ba (1) , Lei Lei, Yao Zheng, Xin Deng, Weijun Li, Peng Liu, Yongshen Ren(*). Investigation on the Optimum Preparation of Peach Gum Polysaccharides and Its Therapeutic Effects and Mechanisms on Acute Pyelonephritis in Vivo and Vitro. Evidence-based Complementary and Alternative Medicine. 2109,https://doi.org/10.1155/2019/2729343【SCI三区，IF=1.984】
[4] Yongshen Ren(1,*) , Yao Zheng(1), Lei Lei, Xin Deng, Xinqiao Liu, Xukun Deng (*). Dandelion polyphenols protect against acetaminophen induced hepatotoxicity in mice via activating the Nrf-2/HO-1 and inhibiting the JNK signaling pathway. Chin J Nat Med. 2020.1 【SCI三区，IF=1.773】
[5] Yongshen Ren, Ziliang Yuan, Kangle Lv, Jie Sun, Zehui Zhang(*) , Quan Chi. Selective and metal-free oxidation of biomass derived 5-hydroxymethylfurfural to 2,5-diformylfuran over nitrogen-doped carbon materials. Green Chemistry. 2018. 20: 4946【SCI一区，IF=8.586】
[6] Yongshen Ren, Yanxin Wang, Xun Li, Zehui Zhang(*), Quan Chi. Selective hydrogenation of quinolines into 1,2,3,4-tetrahydroquinolines over a nitrogen doped carbon-supported Pd catalyst. New J. Chem. 2018. 42, 16694-16702【SCI三区，IF=3.201】
[7] Jie Yang, Shihao Deng, Mi Huang, Xinhua Ma, Ping Song, Jingwen Du, Yun Huang, Yanzhang Wen, Yongshen Ren(*), Xinzhou Yang(*). Inhibitory effect of kurarinone on growth of human non-small cell lung cancer: an experimental study both in vitro and in vivo studies. Fronters in Pharmacology Ethnopharmacology. 2018. DOI: 10.3389/fphar.2018.00252 【 SCI二区，IF=3.831】
[8] Wing Lam, Ren Yongshen, Fulan Guan, Zaoli Jiang, William Cheng, Shwuhuey Liu, Yung-Chi Cheng(*). Mechanism Based Quality Control (MBQC) for quality control of herbal products: a case study YIV-906 (PHY906). Fronters in Pharmacology Ethnopharmacology. 2018. doi: 10.3389/fphar.2018.01324【 SCI二区，IF=3.831】
[9] Yongshen Ren, Bing Liu, Zehui Zhang, Jintao Lin, Silver-exchanged heteropolyacid catalyst (Ag1H2PW): An efficient heterogeneous catalyst for the synthesis of 5-ethoxymethylfurfural from 5-hydroxymethylfurfural and fructose，Journal of Industrial and Engineering Chemistry. 2015, 21: 1127-1131【 SCI二区，IF=4.421】
[10] Yongshen Ren(*, 1), Jiao Ai (1), Xinqiao Liu, Shuai Liang, Yao Zheng, Xin Deng, Yan Li, Jing Wang, Linlin Chen, Zhinan Mei(*) . Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational analysis combined with UPLC-MS and molecular docking. J Ethnopharm. 【 SCI二区，IF=3.414】
[11] Liang shuai, Zheng Yao, Lei Lei, Deng Xin, Ren Yongshen(*).The protective effect of Corydalis on Alzheimer's disease by the inhibitions of NF-κB/MAPK pathway. J Ethnopharmacol. 2020 (In review) 【SCI二区，IF=3.414 】
[12] Yao Zheng (1), Lei Lei (1), Shuai Liang, Jiao Ai , Yongshen Ren (*) .Comparative study on the protective effect of fresh/dry dandelion extracts on APAP-overdose caused acute liver Injury . Planta Medica. 2020 (In review) 【SCI二区，IF=2.746 】
[13] Manrong Tan (1)，Yongshen Ren (1)，Yan Dan(*)，Mengxiang Hong，Longhu Chen，Lingling Qiu，Yan Yan，Jianyu Li，Xiaohe Xiao(*)，Detection of microorganisms in different growth states basedon microcalorimetry，J Therm Anal Calorim，2012, 109: 1069-1075【 SCI三区，IF=1.953】
[14] Yongshen Ren，Ping Zhang，Dan Yan，Yan Yan，Longhu Chen，Lingling Qiu，Zhinan Mei，Xiaohe Xiao，Application ofmicrocalorimetryof Escherichia coli growth and discriminant analysis to th equality assessment of a Chinese herbal injection(Yinzhihuang). Acta Pharmaceutica Sinica B，2012,2(2): 278-285【SCI一区，IF=6.014】
[15] Yongshen Ren (1)，Ping Zhang (1)，Yan Dan (*) ，JB Wang，Xiaoxi Du，XiaoHe Xiao (*). A strategy for the detection of quality fluctuation of a Chinese herbal injection based on chemical fingerprinting combined with biological fingerprinting.，J Pharm Biomed Anal., 2011, 56(2): 436-442 【 SCI三区，IF=2.831】
